Corticomotor facilitation associated with observation and imagery of hand actions is impaired in Parkinson's disease
Identifieur interne : 002411 ( Main/Exploration ); précédent : 002410; suivant : 002412Corticomotor facilitation associated with observation and imagery of hand actions is impaired in Parkinson's disease
Auteurs : Francois Tremblay [Canada] ; Guillaume Leonard [Canada] ; Louis Tremblay [Canada]Source :
- Experimental brain research [ 0014-4819 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
In the present report, we extend our previous observations on corticomotor facilitation associated with covert (action observed or imagined) and overt (action imitated) action execution in old adults (Leonard and Tremblay in Exp Brain Res 117:167-175, 2007) to investigate the impact of Parkinson's disease (PD). Participants consisted of 22 older adults (age range 58-76 years) of whom 11 were medicated patients diagnosed with PD (patient group) and 11 were age-matched healthy controls (healthy group). Corticomotor facilitation was assessed by monitoring the changes in the amplitude of motor evoked potentials (MEP) in muscles of the right hand (first dorsal interosseous: FDI; and abductor digiti minimi: ADM) in response to transcranial magnetic stimulation of the left motor cortex. In each group, corticomotor facilitation was assessed with participants seated in front of a computer screen under four testing conditions: (1) REST: eyes closed and instructions to relax for 10 s, (2) OBS: observe action, (3) IMAG: imagine action and (4) IMIT: imitate action. The action depicted in the video displayed the hand of a male subject cutting a piece of material with scissors. Comparison of variations in MEP amplitude revealed a significant interaction between groups and conditions. In the healthy group, the OBS and IMAG conditions were both associated with significant facilitation in the FDI and ADM, whereas the same conditions failed to produce facilitation in the PD group. In both groups, the IMIT condition produced the largest facilitation in hand muscles. Further planned comparisons revealed a significant difference between groups in the FDI for the OBS condition. From these findings, we conclude that, even when properly medicated, old adults with PD may experience major difficulties in engaging the motor system for covert actions, particularly when asked to observe another person's action. This failure of corticomotor facilitation for covert actions appears to be linked with the deficit in motor activation associated with basal ganglia dysfunction in PD and in line with the difficulty experienced in general by patients "to energize" the motor system in preparation for action.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000665
- to stream PascalFrancis, to step Curation: 000645
- to stream PascalFrancis, to step Checkpoint: 000561
- to stream Main, to step Merge: 002622
- to stream Main, to step Curation: 002411
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Corticomotor facilitation associated with observation and imagery of hand actions is impaired in Parkinson's disease</title><author><name sortKey="Tremblay, Francois" sort="Tremblay, Francois" uniqKey="Tremblay F" first="Francois" last="Tremblay">Francois Tremblay</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Rehabilitation Sciences, University of Ottawa</s1><s2>Ottawa, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON</wicri:noRegion></affiliation></author><author><name sortKey="Leonard, Guillaume" sort="Leonard, Guillaume" uniqKey="Leonard G" first="Guillaume" last="Leonard">Guillaume Leonard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Rehabilitation Sciences, University of Ottawa</s1><s2>Ottawa, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON</wicri:noRegion></affiliation></author><author><name sortKey="Tremblay, Louis" sort="Tremblay, Louis" uniqKey="Tremblay L" first="Louis" last="Tremblay">Louis Tremblay</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Rehabilitation Sciences, University of Ottawa</s1><s2>Ottawa, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0135370</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0135370 INIST</idno><idno type="RBID">Pascal:08-0135370</idno><idno type="wicri:Area/PascalFrancis/Corpus">000665</idno><idno type="wicri:Area/PascalFrancis/Curation">000645</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000561</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000561</idno><idno type="wicri:doubleKey">0014-4819:2008:Tremblay F:corticomotor:facilitation:associated</idno><idno type="wicri:Area/Main/Merge">002622</idno><idno type="wicri:Area/Main/Curation">002411</idno><idno type="wicri:Area/Main/Exploration">002411</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Corticomotor facilitation associated with observation and imagery of hand actions is impaired in Parkinson's disease</title><author><name sortKey="Tremblay, Francois" sort="Tremblay, Francois" uniqKey="Tremblay F" first="Francois" last="Tremblay">Francois Tremblay</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Rehabilitation Sciences, University of Ottawa</s1><s2>Ottawa, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON</wicri:noRegion></affiliation></author><author><name sortKey="Leonard, Guillaume" sort="Leonard, Guillaume" uniqKey="Leonard G" first="Guillaume" last="Leonard">Guillaume Leonard</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Rehabilitation Sciences, University of Ottawa</s1><s2>Ottawa, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON</wicri:noRegion></affiliation></author><author><name sortKey="Tremblay, Louis" sort="Tremblay, Louis" uniqKey="Tremblay L" first="Louis" last="Tremblay">Louis Tremblay</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Rehabilitation Sciences, University of Ottawa</s1><s2>Ottawa, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abductor digiti minimi muscle</term><term>Dorsal interosseous muscle</term><term>Encephalon</term><term>Evoked potential</term><term>Eye</term><term>Facilitation</term><term>Hand</term><term>Human</term><term>Magnetic stimulus</term><term>Monitoring</term><term>Motor cortex</term><term>Motor evoked potential</term><term>Parkinson disease</term><term>Transcranial magnetic stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Facilitation</term><term>Main</term><term>Encéphale</term><term>Monitorage</term><term>Potentiel évoqué moteur</term><term>Potentiel évoqué</term><term>Muscle interosseux dorsal</term><term>Muscle abducteur petit doigt</term><term>Maladie de Parkinson</term><term>Stimulation magnétique transcrânienne</term><term>Stimulus magnétique</term><term>Cortex moteur</term><term>Oeil</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present report, we extend our previous observations on corticomotor facilitation associated with covert (action observed or imagined) and overt (action imitated) action execution in old adults (Leonard and Tremblay in Exp Brain Res 117:167-175, 2007) to investigate the impact of Parkinson's disease (PD). Participants consisted of 22 older adults (age range 58-76 years) of whom 11 were medicated patients diagnosed with PD (patient group) and 11 were age-matched healthy controls (healthy group). Corticomotor facilitation was assessed by monitoring the changes in the amplitude of motor evoked potentials (MEP) in muscles of the right hand (first dorsal interosseous: FDI; and abductor digiti minimi: ADM) in response to transcranial magnetic stimulation of the left motor cortex. In each group, corticomotor facilitation was assessed with participants seated in front of a computer screen under four testing conditions: (1) REST: eyes closed and instructions to relax for 10 s, (2) OBS: observe action, (3) IMAG: imagine action and (4) IMIT: imitate action. The action depicted in the video displayed the hand of a male subject cutting a piece of material with scissors. Comparison of variations in MEP amplitude revealed a significant interaction between groups and conditions. In the healthy group, the OBS and IMAG conditions were both associated with significant facilitation in the FDI and ADM, whereas the same conditions failed to produce facilitation in the PD group. In both groups, the IMIT condition produced the largest facilitation in hand muscles. Further planned comparisons revealed a significant difference between groups in the FDI for the OBS condition. From these findings, we conclude that, even when properly medicated, old adults with PD may experience major difficulties in engaging the motor system for covert actions, particularly when asked to observe another person's action. This failure of corticomotor facilitation for covert actions appears to be linked with the deficit in motor activation associated with basal ganglia dysfunction in PD and in line with the difficulty experienced in general by patients "to energize" the motor system in preparation for action.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Tremblay, Francois" sort="Tremblay, Francois" uniqKey="Tremblay F" first="Francois" last="Tremblay">Francois Tremblay</name></noRegion><name sortKey="Leonard, Guillaume" sort="Leonard, Guillaume" uniqKey="Leonard G" first="Guillaume" last="Leonard">Guillaume Leonard</name><name sortKey="Tremblay, Louis" sort="Tremblay, Louis" uniqKey="Tremblay L" first="Louis" last="Tremblay">Louis Tremblay</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002411 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002411 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:08-0135370
|texte= Corticomotor facilitation associated with observation and imagery of hand actions is impaired in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.29. |  |